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Prepare your injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it.

Call your pharmacist for new medicine. Your care provider will show you the best places on your body to inject Simponi. Use a different place each time you give an injection.

Do not inject into the same place two times in a row. Each single-use prefilled syringe or auto-injector device is for one use only.

Throw it away after one use, even if there is still medicine left inside. Store the medication in its original carton in the refrigerator, do not freeze.

Protect from light. Take the medicine out of the refrigerator and let it reach room temperature for 30 minutes before injecting your dose. Do not warm the medication with water or heat.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container.

Keep it out of the reach of children and pets. Initial dose: 50 mg subcutaneously once a month Comments: -Psoriatic arthritis or ankylosing spondylitis: May be administered with or without methotrexate or other non-biologic Disease Modifying Antirheumatic Drugs DMARDs.

Initial dose: mg subcutaneously at week 0, followed by mg at week 2. Maintenance dose: mg subcutaneously every 4 weeks. Initial dose: 50 mg subcutaneously SC once a month or 2 mg per kg intravenous IV infusion over 30 minutes at weeks 0 and 4, then every 8 weeks thereafter.

Comments: It should be given in combination with methotrexate. Simponi dosage information in more detail. Use the medicine as soon as you remember, and then go back to your regular injection schedule.

Do not use two doses at one time. Do not receive a "live" vaccine while using Simponi, and avoid coming into contact with anyone who has recently received a live vaccine.

There is a chance that the virus could be passed on to you. Live vaccines include measles , mumps, rubella MMR , rotavirus, typhoid, yellow fever, varicella chickenpox , zoster shingles , and nasal flu influenza vaccine.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection. Get emergency medical help if you have signs of an allergic reaction to Simponi: hives , itching; nausea ; chest pain, difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor right away if you have signs of infection such as:. This is not a complete list of side effects and others may occur.

Call your doctor for medical advice about side effects. Simponi side effects in more detail. This list is not complete.

Other drugs may interact with golimumab, including prescription and over-the-counter medicines, vitamins , and herbal products.

Not all possible drug interactions are listed here. Simponi drug interactions in more detail. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Simponi only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Other brands: Simponi Aria. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

Available for Android and iOS devices. Subscribe to Drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

Skip to Content. See also: Simponi dosage information in more detail. See also: Simponi side effects in more detail.

See also: Simponi drug interactions in more detail. Drug Status Availability Prescription only Rx. Janssen Pharmaceuticals, Inc.

Drug Class. TNF alfa inhibitors. This mirrors other Siouan stories of Thunderbirds facing off against evil snake monsters. Like other Native Americans in interaction with other peoples, the Sappony intermarried.

In some of the early Spanish and Portuguese colonies, mulatto meant mixed-race African and Native American, but under the English tradition, it came to mean persons of European and African ancestry.

But in other parts of the South, race was considered a more fluid concept, with mixed-race people being classified as "white", "Indian", "negro", "mulatto", or sometimes even "Mexican", as the situation suited them.

In Maryland , the Catholic Church kept records that recognized its Indian parishioners identifying as Native American; these have helped some descendants prove continuity of communities.

Because South Carolina taxed American Indian slaves at a lesser rate than African slaves as early as , that colony had legislated that "all such slaves as are not entirely Indian shall be accounted as negro.

Wright in , Virginia tended to classify persons of mixed Native American and African ancestry as 'Negroes', a decision that favored slaveholders after Indian slavery was ended.

Colonial and early United States governments generally failed to recognize how people identified culturally.

The problem grew more severe at the turn of the 19th century, resulting in records that are biased toward classifying all free people of color as African American, when some identified culturally and by descent as members of specific Native American tribes.

There have been many academic disagreements about the cultural identity of numerous people recorded simply as free blacks or free people of color.

Jack Forbes has noted that the terms "mustees" and "mulattoes" at one time referred to persons of part American [Indian] ancestry.

A mustee may have been primarily part-African and American [Indian], and a mulatto was usually part-European and American [Indian], but the latter term particularly was used more generally to refer to mixed-race people of African American and European ancestry.

At the time, the federal censuses had no classification for American Indian, and did not ask people with which culture they identified. Paul Heinegg and Virginia DeMarce have found that a high percentage of people identified as "free blacks" or "free people of color" in federal censuses from — when there was no designation for Indian in the Upper South were descended from families classified as free African Americans in colonial Virginia.

Most were free because they were descended from unions between white women who were free and African or African-American men. Their children and descendants maintained this free status.

At the time, most working-class people shared living and working quarters. These families were documented through extensive research in colonial records of Virginia and the Chesapeake Bay Colony, including court records, land deeds, wills and manumissions.

Some free African Americans were descended from enslaved Africans freed by owners as early as the midth century.

By the early decades of the 19th century, such free families had many descendants; they often moved to frontier areas where racial strictures were reduced.

In some cases, descendants married more into one or another of their ancestral communities, becoming increasingly white, black or Indian.

Issues about identity became more confusing under Jim Crow in the late 19th century as white Democrats imposed racial segregation to enforce white supremacy.

In the 20th century, as both North Carolina and Virginia adopted one-drop rules as part of their racial segregation laws, requiring all individuals to be classified as either white or black essentially, all other or all people of color.

They classified as black any person with any black ancestry, regardless of how small. Walter Ashby Plecker , the Registrar of Virginia's Bureau of Vital Statistics, issued orders to field offices to change birth records of individuals whose families he had decided were trying to pass as Indian to avoid being classified as black.

Due to his application of the Racial Integrity Act , records of many Native American-identified people were changed without their consent, and often without their knowledge.

In later years, their descendants have had difficulty in proving their communities' continuity of identity. Three groups, each recognized by the state of North Carolina , claim descent from the historical Sappony.

The Haliwa-Saponi , a group based chiefly in Halifax and Warren counties, is another Native American band formally recognized by North Carolina in They organized that year under the name Haliwanash Indian Club.

They changed their name in to include a reference to the historic Sappony. The North Carolina Auditors became involved at that time.

In it added Saponi to its name. Members were observed to have or claimed European, African and Native American ancestry, to varying degree.

Some such groups settled and created communities in frontier and border areas of the southern states, where there was initially a lower level of development of plantations.

These two communities each stressed cultural identification with historic American Indians. Their applications for recognition as American Indian tribes were approved by the state of North Carolina in and , respectively.

Ohio is home to the second-largest population of people claiming Saponi ancestry; the Ohio Saponi community was established by migrants from Halifax, Warren, [22] Orange, Alamance, Granville, [23] and Robeson counties of North Carolina and bordering counties in Virginia.

These families migrated to the Midwest in response to a period of intensified violent oppression of free people of color in the South that extended from approximately to This period of oppression was codified in a set of legislative acts that included federal laws such as the Indian Removal Act of , which set off a period of attempted violent removals of Native Americans from the entirety of the Southeast that resulted in at least 19, deaths on the Trail of Tears , as well as state laws such as the North Carolina Constitution of , which removed the right of free Native Americans and African-Americans to vote; [24] and the Act Concerning Slaves and Free Persons of Color , which restricted the residencies and movement of free Native Americans or African-Americans, and also prohibited them from serving as witnesses in courts of law.

The Haliwa-Saponi Tribal History describes the cause of the migration as follows: "In North Carolina amended its constitution and barred people of color from voting and participating in the government.

Many Haliwa-Saponi families reacted by migrating to areas north and west such as Chillicothe, Ohio, which had more favorable laws for non-white peoples.

Other families chose to continue their lives in the Meadows. Marty Richardson further writes, "A large group of Meadows Indians migrated to Ohio after and took advantage of fewer race-based restrictions.

Their migration provided more economic opportunities, education, freedom of movement, and inspired Civil War military service as part of the U.

Colored Troops. Those who stayed in the Meadows faced another challenge in , after the end of the Civil War and emancipation. They developed social and religious institutions to maintain their distinct identity as Natives, while also exercising rights as Americans.

Using institutions such as landownership, family, the military, and church, Meadows Indians debated the consequences of these changes and how they could keep their core identity markers alive.

In the present day, members of midwestern Saponi communities are dispersed across multiple counties in Ohio, Indiana, and Michigan.

Members generally belong to one of three self-organized tribes based in Ohio; the largest of these is the Saponi Nation of Ohio.

Other non-tribal organizations include the Saponi Descendants Association based in Texas. A group previously organized but now apparently defunct was called the Manahoac Sappony Mattamuskeet Nation, and was based in Georgia.

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Sponi

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